Sodium Hydroxide → HCID 68429191, compound

Participants

Reaction Steps

4-Chloro-2-{2-[4-(diethylamino)phenyl]-2-oxoethyl-}-5-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-3(2H)-one (42 mg, 0.0891 mmol) in tetrahydrofuran (2 mL) was added dropwise to lithium aluminum hydride (11 mg, 0.315 mmol) in tetrahydrofuran (2 mL) at 0° C. and stirred at room temperature for 10 minutes. After completion of the reaction, the reaction solution was mixed with aqueous sodium hydroxide, anhydrous, sodium sulfate, then filtered and evaporated under reduced pressure. The residue was purified by preparative thin layer chromatography (hexane/ethyl acetate=1/1) to give the desired product (14 mg, 33% yield).

Provenance & Evidence