Ethyl bromoacetate → HCID 70823496, compound

Participants

Reaction Conditions

Reaction Steps

2-[5-Chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl]-N-[(3-hydroxypyridin-4-yl)methyl]acetamide (12.7 mg, 0.03 mmol) in acetone (2 mL) was mixed with ethyl bromoacetate (4.4 μL, 0.04 mmol) and potassium carbonate (5.9 mg, 0.04 mmol) at room temperature and stirred at 50° C. for 1 hour. After cooling, the reaction solution was mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The resulting organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/methanol=20/1) to give the desired product (4.8 mg, 30%).

Provenance & Evidence