Potassium Carbonate → HCID 68430621, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromo-5-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-3(2H)-one (112.8 mg, 0.35 mmol) in N,N-dimethylformamide (2 mL) was mixed with ethyl 1-bromocyclobutanecarboxylate (85.8 μL, 0.53 mmol) and potassium carbonate (73.0 mg, 0.53 mmol) at room temperature and stirred at 150° C. for 2 hours in a microwave reactor. After cooling, the reaction solution was mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The resulting organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting crude product containing the desired product was used for the next reaction (222.1 mg).

Provenance & Evidence