Dimethylformamide dimethyl acetal → HCID 136343209, compound

Participants

Reaction Steps

2-[5-Chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl]acetamide (32 mg, 0.0944 mmol) in tetrahydrofuran/N,N-dimethylformamide (1/0.1 mL) was stirred with 1,1-dimethoxy-N,N-dimethylmethanamine (25 μL, 0.188 mmol) at room temperature for 3 hours. The reaction solution was concentrated and stirred with tetrahydrofuran/water (1/2 mL) and methoxyamine hydrochloride (12 mg, 0.143 mmol) at room temperature for 2 hours. After completion of the reaction, the reaction solution was mixed with water and extracted with ethyl acetate, and the extract was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give the desired product (29 mg, 78% yield).

Provenance & Evidence