(Diethylamino)sulfur trifluoride → HCID 68429306, compound

Participants

Reaction Conditions

Reaction Steps

rac-2-[5-Bromo-4-{[2-(hydroxymethyl)-6,6-dimethylbicyclo[3.1.1]hept-3-yl]amino}-6-oxopyridazin-1(6H)-yl]-N-(pyridin-4-ylmethyl)acetamide (43 mg, 0.0877 mmol) in dichloromethane (3 mL) was mixed with (diethylamino)sulfur trifluoride (17 μL, 0.128 mmol) at ˜78° C. and stirred at −78° C. for 10 minutes and then stirred at room temperature for 1 hour. After completion of the reaction, the reaction solution was mixed with saturated aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting residue was purified by thin layer silica gel chromatography (chloroform/methanol=10/1) to give the desired product (16% yield).

Provenance & Evidence