1,4-Dioxane hydrochloride → HCID 68432000, compound

Participants

Reaction Conditions

Reaction Steps

2-(5-Chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl)-N-[1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-4-yl)ethyl]acetamide (56.2 mg, 0.10 mmol) was mixed with 4 M hydrogen chloride/1,4-dioxane (2 mL) and stirred at 100° C. for 5 hours. After completion of the reaction, the reaction solution was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/MeOH=20/1) to give the desired product (5.2 mg, 12% yield).

Provenance & Evidence