Water → HCID 59393687, compound

Participants

Reaction Steps

Methanesulfonyl chloride (28.0 μL, 0.362 mmol) was added to a stirred solution of 1d (104 mg, 0.241 mmol) and N,N-diisopropylethylamine (105 μL, 0.602 mmol) in DCM (2.00 mL) at 0° C. After approximately 20 min, the reaction mixture was poured into water and extracted three times with EtOAc. The combined organic extracts were washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound 1e, which was used without further purification.

Provenance & Evidence