Water → N-(6-methyl-3,4-dihydro-2H-chromen-4-yl)-N'-quinolin-5-ylurea

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Reaction Steps

This compound was made following the procedure of Example 5, except substituting 5-aminoquinoline for 5-aminoisoquinoline and 6-methyl-chroman-4-ylamine for 7-trifluoromethyl-chroman-4-ylamine. 1H NMR (300 MHz, DMSO-d6) δ 8.90 (m, 1H), 8.60 (s, 1H), 8.47 (m, 1H), 8.18 (m, 1H), 7.68 (m, 2H), 7.57 (m, 1H), 7.16 (m, 1H), 7.08 (d, J=7.5 Hz, 1H), 7.00 (m, 1H), 6.71 (d, J=7.5 Hz, 1H), 4.93 (m, 1H), 4.31-4.10 (m, 2H), 2.21 (s, 3H), 2.20-1.93 (m, 2H). MS (ESI) m/e 334 (M+H)+. Calcd. For C20H19N3O2.0.1; H2O: C, 71.67; H, 5.77; N, 12.54. Found: C, 71.65; H, 5.83; N, 12.30.

Provenance & Evidence