HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 53251495, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Aminoisoquinoline | HCID 70766 | — |
| Reactant | 6-Chloro-7-methyl-3,4-dihydro-2H-1-benzopyran-4-amine | HCID 16643029 | — |
| Reactant | 7-(Trifluoromethyl)chroman-4-amine | HCID 46835421 | — |
| Product | HCID 53251495 | HCID 53251495 | — |
Reaction Steps
The title compound was prepared using the procedure as described in Example 5, substituting 5-aminoquinoline for 5-aminoisoquinoline and substituting the product of Example 13B for the product of Example 4D. 1H NMR (300 MHz, DMSO-d6) δ 8.90 (m, 1H), 8.62 (s, 1H), 8.47 (m, 1H), 8.12 (m, 1H), 7.70 (m, 2H), 7.58 (m, 1H), 7.31 (s, 1H), 7.07 (d, J=7.5 Hz, 1H), 7.18-7.00 (m, 3H), 6.82 (s, 1H), 4.91 (m, 1H), 4.33-4.10 (m, 2H), 2.24 (s, 3H), 2.20-1.92 (m, 2H). MS (ESI) m/e 368 (M−H)+. Calcd. For C20H18N3O2Cl.0.2; H2O: C, 64.67; H, 4.99; N, 11.31. Found: C, 64.85; H, 4.90; N, 11.02.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440691B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-213a1244910b4b43847481e84c42f658 |
| Source note | uspto-grants-2013_05 |