tert-Butyl octahydro-5H-pyrrolo(3,4-c)pyridine-5-carboxylate → tert-butyl 2-(3-(3-(trifluoromethoxy)phenylsulfonyl)quinolin-8-yl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

HRID 2092197Notes

Reaction equation

HRID 2092197 reaction equation
[CH2:1]1[CH:9]2[CH:4]([CH2:5][N:6]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7][CH2:8]2)[CH2:3][NH:2]1.I[C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[N:26]=[CH:25][C:24]([S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([O:37][C:38]([F:41])([F:40])[F:39])[CH:32]=1)(=[O:30])=[O:29])=[CH:23]2>>[F:41][C:38]([F:39])([F:40])[O:37][C:33]1[CH:32]=[C:31]([S:28]([C:24]2[CH:25]=[N:26][C:27]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][C:18]=3[N:2]2[CH2:1][CH:9]3[CH:4]([CH2:5][N:6]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7][CH2:8]3)[CH2:3]2)(=[O:29])=[O:30])[CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 19691292tert-Butyl octahydro-5H-pyrrolo(3,4-c)pyridine-5-carboxylateHCID 687290868-Iodo-3-(3-(trifluoromethoxy)phenylsulfonyl)quinoline

Product 1

HCID 25196511tert-butyl 2-(3-(3-(trifluoromethoxy)phenylsulfonyl)quinolin-8-yl)hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylateYield 54%

Procedure

The title compound was prepared by analogy to the procedure of Example 1.3, except using tert-butyl hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate and 8-iodo-3-(3-(trifluoromethoxy)phenylsulfonyl)quinoline. 130 mg (54%) of the title compound were obtained as a pale yellow solid.

Workup

  1. customThe title compound was prepared by analogy to the procedure of Example 1.3

Sources & evidence

ORD record
ord-2abb906375874055bf6f4d9eb8afdd95
Source dataset
uspto-grants-2013_05
Patent number
US08440694B2

Reaction notes

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