370879-92-8 → HCID 68729023, compound

HRID 2092213Notes

Reaction equation

HRID 2092213 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3I)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH2:22]([N:29]1[CH2:33][CH2:32][C@H:31]2[CH2:34][NH:35][CH2:36][C@@H:30]12)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([N:29]1[CH2:33][CH2:32][C@H:31]2[CH2:34][N:35]([C:15]3[CH:16]=[CH:17][CH:18]=[C:19]4[C:14]=3[N:13]=[CH:12][C:11]([S:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)(=[O:10])=[O:9])=[CH:20]4)[CH2:36][C@@H:30]12)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 43423275370879-92-8HCID 673141573-(3-Fluorophenylsulfonyl)-8-iodoquinoline

Product 1

HCID 68729023HCID 68729023, compound

Procedure

0.157 g of 8-((3aS,6aS)-1-benzylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-3-(3-fluorophenylsulfonyl)quinoline were prepared by analogy to the method of Example 27 by coupling of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline with (3aS,6aS)-1-benzyloctahydropyrrolo[3,4-b]pyrrole

Sources & evidence

ORD record
ord-627b8917e65d4c87a61806e89b72f079
Source dataset
uspto-grants-2013_05
Patent number
US08440694B2

Reaction notes

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