HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-Hydrazino-butan-2-ol → (S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3-methoxy-5-trifluoromethyl-phenylamino)-[1,2,4]triazol-1-yl]butan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-Hydrazino-butan-2-ol | HCID 28082624 | — |
| Reactant | 1-(2-Chloro-6-methyl-pyridine-4-carbonyl)-3-(3-methoxy-5-trifluoromethyl-phenyl)-2-methyl-isothiourea | HCID 136116019 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3-methoxy-5-trifluoromethyl-phenylamino)-[1,2,4]triazol-1-yl]butan-2-ol | HCID 86644738 | — |
Reaction Steps
A mixture of intermediate D6 (8.356 g, 0.020 mol) and intermediate D3 (2.083 g, 0.020 mol) in ethanol (200 ml) was stirred overnight at reflux. Subsequently, the solvent was evaporated to yield intermediate D7 (S-enantiomer) as a yellow oil that was used as such in the next reaction step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440701B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-cc7f36bb7fdf4c8aa52c4d36de27cd7f |
| Source note | uspto-grants-2013_05 |