反应详情

100 mg (0.43 mmol) of the compound from Example 44A, together with 0.24 ml (3.24 mmol) of thionyl chloride, are stirred at RT for 8 h. The excess thionyl chloride is removed under reduced pressure and the residue is taken up in about 5 ml of ethyl acetate. The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure. The product obtained is used without further purification in the subsequent reactions.

1. customThe excess thionyl chloride is removed under reduced pressure
2. washThe mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. dry with materialThe organic phase is dried over magnesium sulfate
4. customthe solvent is removed under reduced pressure
5. customThe product obtained
6. customis used without further purification in the subsequent reactions