HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2092265Generated: October 30, 2026
p-Toluenesulfonic acid → 5-Bromopyrazolo[3,4-b]pyridine
https://huagongshe.com/reaction/2092265
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 5-Bromo-2-fluoro-3-pyridinecarboxaldehyde | HCID 45480192 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-Bromopyrazolo[3,4-b]pyridine | HCID 40427454 | — |
Reaction Steps
A mixture of 5-bromo-2-fluoronicotinaldehyde (0.580 g, 2.8 mmol), 4-methylbenzenesulfonic acid (0.060 g, 0.35 mmol) and anhydrous hydrazine (0.450 ml, 14 mmol) in 5 mL of i-PrOH was heated at 145° C. for 15 min in the microwave (Initiator by Biotage). The reaction was diluted with H2O and the solid was filtered washed with H2O and air-dried to give a white amorphous solid. MS (M+H)+ 198, 200.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440674B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-27a78b77ed214417b9b4546aaba7f86f |
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| Source note | uspto-grants-2013_05 |
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