HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Indan-5-amine | HCID 90496 | — |
| Reactant | 4-Chloro-8-iodo-7-methylquinazoline | HCID 58466484 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride | HCID 67338686 | 87% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
2,3-Dihydro-1H-inden-5-amine (109 mg, 821 μmol), 4-chloro-8-iodo-7-methylquinazoline (250 mg, 821 μmol) and IPA (5 mL) were added to microwave-vial. The reaction mixture was heated at 110° C. for 10 min. A precipitate formed upon cooling. The crude product was diluted with EtOAc (20 mL), filtered, washed twice with EtOAc (20 mL) and air-dried to give N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride (311 mg, 87%) as an amorphous off-white solid. MS (M+H)+ 402.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-4836f89861564e24bb3dba7f6fc63000 |
| Source note | uspto-grants-2013_05 |