HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2092295Generated: October 31, 2026
Hydrazine hydrate (1:1) → 6-(3-(3-isopropoxyphenylamino)-6-methyl-1H-indazol-7-yl)-N-methylquinazolin-2-amine
https://huagongshe.com/reaction/2092295
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 58829668 | HCID 58829668 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 6-(3-(3-isopropoxyphenylamino)-6-methyl-1H-indazol-7-yl)-N-methylquinazolin-2-amine | HCID 67340204 | — |
Reaction Steps
A mixture of 2-fluoro-N-(3-isopropoxyphenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzothioamide (54 mg, 117 μmol) and hydrazine hydrate (11 μL, 234 μmol) in n-butanol (6 mL) was heated in a microwave reactor at 150° C. for 33 min. Solvent was removed and the residue was purified by preparative TLC (50% EtOAc/hexane) to give the title compound. MS (M+H)+ 439.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440674B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-fc884b9f4cd84b5e81af428372815b77 |
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| Source note | uspto-grants-2013_05 |
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