反应详情

Compound 75 (8.25 g, 14.9 mmol) was dissolved in methanol (20 mL) and purged with argon. To the solution was added 10% palladium on carbon (0.825 g). The flask was purged with hydrogen 2 times and stirred further at room temperature under hydrogen atmosphere for 3 h. The disappearance of the starting material was confirmed by the TLC. The reaction mixture was filtered through a pad of Celite and washed with methanol. The combined organic layer was concentrated under reduced pressure to afford amine 76 (6.12 g, 98%) as white solid. This was used as such for the next step.

1. custompurged with argon
2. additionTo the solution was added 10% palladium on carbon (0.825 g)
3. customThe flask was purged with hydrogen 2 times
4. filtrationThe reaction mixture was filtered through a pad of Celite
5. washwashed with methanol
6. concentrationThe combined organic layer was concentrated under reduced pressure