HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Diethyl 2-((2-oxo-1,2-dihydropyridin-3-ylamino)methylene)malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 3-Amino-2-pyridinol | HCID 322353 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Diethyl 2-((2-oxo-1,2-dihydropyridin-3-ylamino)methylene)malonate | HCID 12868403 | 63.3% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
3-Aminopyridin-2(1H)-one (9.00 g, 81.7 mmol) was treated with diethyl ethoxymethylenemalonate (24.6 ml, 123 mmol) and heated to 100° C. After 3 hours, the reaction was cooled down and diluted with isopropyl alcohol. The solid that crashed out was collected by suction filtration and washed well with IPA and then ether to give diethyl 2-((2-oxo-1,2-dihydropyridin-3-ylamino)methylene)malonate (14.5 g, 63.3% yield) as a greenish solid. MS(M+H)+ 281.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-5259ed6de34a408abab69647f7dedecb |
| Source note | uspto-grants-2013_05 |