Pyridine → HCID 59140283, compound

HRID 2092357Notes

Reaction equation

HRID 2092357 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:17]3[C:12](=[C:13]4[CH:21]=[CH:20][CH:19]=[CH:18][C:14]4=[CH:15][CH:16]=3)[NH:11][C:10](=[O:22])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24].N1C=CC=CC=1>O>[O:22]=[C:10]1[CH2:9][CH:8]([C:4]2[CH:3]=[C:2]([NH:1][C:23](=[O:25])[CH3:24])[CH:7]=[CH:6][CH:5]=2)[C:17]2[C:12](=[C:13]3[CH:21]=[CH:20][CH:19]=[CH:18][C:14]3=[CH:15][CH:16]=2)[NH:11]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 59140362HCID 59140362, compound

Product 1

HCID 59140283HCID 59140283, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-(3-Amino-phenyl)-3,4-dihydro-1H-benzo[h]quinolin-2-one (0.25 g, 0.87 mmol), acetic anhydride (1 ml) and anhydrous pyridine (1 ml) was stirred at ambient temperature overnight. Water was added and the precipitate was separated by filtration. Crystallization from methanol-acetonitrile afforded the title compound (0.06 g, 0.18 mmol).

Workup

  1. customthe precipitate was separated by filtration
  2. customCrystallization from methanol-acetonitrile

Sources & evidence

ORD record
ord-30a6c224686240229d5f9e62a65966f6
Source dataset
uspto-grants-2013_05
Patent number
US08440705B2

Reaction notes

Loading…