3,3',5-Trifluorobenzhydrol → HCID 86638972, compound

HRID 2092368Notes

Reaction equation

HRID 2092368 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[F:17][C:18]1[CH:19]=[C:20]([CH:25]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=2)[OH:26])[CH:21]=[C:22]([F:24])[CH:23]=1>>[F:17][C:18]1[CH:19]=[C:20]([CH:25]([O:26][C:10](=[O:11])[O:9][C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)[C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=2)[CH:21]=[C:22]([F:24])[CH:23]=1

Participants

3

Reactant 2

HCID 27607033,3',5-TrifluorobenzhydrolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 86638972HCID 86638972, compound

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with (3,5-difluoro-phenyl)-(3-fluoro-phenyl)-methanol. 1H NMR analysis (300 MHz, DMSO-d6)

Sources & evidence

ORD record
ord-e0a99d31b5714b218cbdd7551ecdd440
Source dataset
uspto-grants-2013_05
Patent number
US08440690B2

Reaction notes

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