3-Fluorobenzhydrol → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-fluoro-phenyl)-phenyl-methyl ester

HRID 2092373Notes

Reaction equation

HRID 2092373 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[F:17][C:18]1[CH:19]=[C:20]([CH:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[OH:25])[CH:21]=[CH:22][CH:23]=1>>[F:17][C:18]1[CH:19]=[C:20]([CH:24]([O:25][C:10](=[O:11])[O:9][C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 5707563-FluorobenzhydrolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 86638977Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-fluoro-phenyl)-phenyl-methyl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with (3-fluoro-phenyl)-phenyl-methanol.

Sources & evidence

ORD record
ord-3093c3774a23446b8f31c38896a417d8
Source dataset
uspto-grants-2013_05
Patent number
US08440690B2

Reaction notes

Loading…