HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → Methyl 3-(methylamino)but-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-(methylamino)but-2-enoate | HCID 2734182 | — |
Reaction Steps
To a solution of methyl acetoacetate (29.4 g, 253 mmol) in methanol (30 mL) was added methylamine (33 wt % in EtOH; 48 mL, 385 mmol) dropwise at room temperature. The reaction was stirred for 1 hour, and then concentrated and dried to give the title compound as a white crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440707B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-2684d5a4adf840a08f84da1cadcb42e5 |
| Source note | uspto-grants-2013_05 |