HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Bromo-3-methylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Bromo-3-methylbenzoic acid | HCID 82131 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-3-methylbenzoyl chloride | HCID 7021534 | — |
Reaction Steps
To 4-bromo-3-methylbenzoic acid (8.6 g, 40.0 mmol) in CH2Cl2 was added DMF (0.4 mL), followed by oxalyl chloride (3.7 mL, 42 mmol) slowly over 10 minutes by syringe. The reaction was stirred for 1 hour at room temperature, and then concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440707B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c7a9283ee04e41db8fea1c97ac211974 |
| Source note | uspto-grants-2013_05 |