o-Fluoroacetophenone → (1S)-1-(2-Fluorophenyl)ethan-1-ol

HRID 2092463Notes

Reaction equation

HRID 2092463 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].B1(C)OC(C2C=CC=CC=2)(C2C=CC=CC=2)[C@@H]2N1CCC2>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:8]([OH:10])[CH3:9]

Participants

3

Reactant 2

HCID 96744o-FluoroacetophenoneHCID 9838490(R)-2-Methyl-CBS-oxazaborolidine

Product 1

HCID 7023576(1S)-1-(2-Fluorophenyl)ethan-1-ol

Procedure

(S)-1-(2-Fluoro-phenyl)-ethanol was prepared according to the procedure described in Example 35, Step 1 using 2′-fluoroacetophenone and (R)-(+)-2-methyl-CBS-oxazaborolidine.

Sources & evidence

ORD record
ord-d9f7d35eeec04245ae8bc4d84a1628ca
Source dataset
uspto-grants-2013_05
Patent number
US08440707B2

Reaction notes

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