反应详情

2′,3′-Difluoroacetophenone (0.337 g, 2.16 mmol) in methanol (15 mL) was treated with sodium borohydride (0.090 g, 2.37 mmol), and the reaction was stirred at room temperature for 30 minutes. The mixture was partitioned between dichloromethane and water, and the organic layer was separated, dried over MgSO4, filtered, and concentrated to give 1-(2,3-difluoro-phenyl)-ethanol.

1. customThe mixture was partitioned between dichloromethane and water
2. customthe organic layer was separated
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated