Ethanone, 1-(2-chlorophenyl)- → 1-Phenylethanol, (S)-

HRID 2092491Notes

Reaction equation

HRID 2092491 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].B1(C)OC(C2C=CC=CC=2)(C2C=CC=CC=2)[C@@H]2N1CCC2>>[C:3]1([C@@H:8]([OH:10])[CH3:9])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

Participants

3

Reactant 2

HCID 72864Ethanone, 1-(2-chlorophenyl)-HCID 9838490(R)-2-Methyl-CBS-oxazaborolidine

Product 1

HCID 4431351-Phenylethanol, (S)-

Procedure

2′-Chloroacetophenone and (R)-(+)-2-methyl-CBS-oxazaborolidine were reacted as described in Example 35, Step 1 to provide (S)-1-phenyl-ethanol.

Sources & evidence

ORD record
ord-6ade6e2b2cce43d983103cc29a0dc6dd
Source dataset
uspto-grants-2013_05
Patent number
US08440707B2

Reaction notes

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