Ammonia → HCID 59253308, compound

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A solution of 4-(2,2,4-trimethyl-5-oxo-1,3-dioxolan-4-yl)phenyl trifluoromethanesulfonate (15.5 g, 0.044 mol) in ammonia solution (30 mL, 7N in methanol) was left under stirring overnight at room temperature. After solvent evaporation under vacuum a crude was obtained that, after purification by flash chromatography (CH2Cl2/MeOH 98:2) afforded pure 2-[4-(trifluoromethanesulfonyloxy)phenyl]-2-hydroxy propanamide (9.7 g, 0.031 mol) as a white solid. Yield 70%. mp 105-107° C. 1H-NMR (CDCl3) δ 7.80 (d, 2H, J=7 Hz), 7.35 (d, 2H, J=7 Hz), 6.50 (bs, 1H, CONH), 5.42 (bs, 1H, CONH), 3.05 (bs, 1H, OH), 1.94 (s, 3H).

Provenance & Evidence