HCID 67328219, compound → HCID 67329151, compound

Participants

Reaction Steps

A solution of 1-(2-Methyl-5-nitro-phenyl)-piperidine-2,4-dione [100 mg, 0.402 mmol] in N,N-Dimethylformamide dimethyl acetal (DMA.DMF) [1 ml] was heated to reflux for 3 hrs. After cooling to room temperature, reaction mixture was concentrated under vacuum. The crude product obtained was further purified by silica gel chromatography using 30-60% ethylacetate/hexane as eluent to obtain pure desired product i.e., 3-Dimethylaminomethylene-1-(2-methyl-5-nitro-phenyl)-piperidine-2,4-dione [9] as dark red solid [Yield: 79.02 mg, 65.02%]

Provenance & Evidence