Sodium Hydroxide → HCID 178484382, compound

Participants

Reaction Steps

N,N-dimethylimidodicarbonimidic diamide hydrochloride (Formula I) (4.06 g, 24.5 mmol) was dissolved in 1N sodium hydroxide (24.5 mL, 24.5 mmol) and stirred at room temperature for 30 minutes. The solution was concentrated in vacuo and to the residue was added EtOH (80 mL). The mixture was carefully concentrated to azeotropically remove water. To the resulting solid was added EtOH (40 mL) and the suspension was filtered to remove precipitated sodium chloride. The filtrate was concentrated and the resulting solid was placed on high vacuum overnight to yield 3.02 g (95%) of metformin free base as a white solid.

Provenance & Evidence