Triacetoxyperiodinane → HCID 58192812, compound

Participants

Reaction Steps

To a solution of (4-Hydroxy-adamantan-1-ylmethyl)-carbamic acid tert-butyl ester (1B) (2.81 g, 10 mmol) in 200 mL of DCM was added Dess martin periodinane (5.08 g, 12 mmol) at one portion at rt. The mixture was stirred at rt overnight and was quenched by 20 mL of NH4Cl aq (Sat'd) solution. The mixture was extracted by DCM (5 mL×3) and the combined DCM layers were dried over Na2SO4. Solvent was remove under vacuum and the residue was purified by silica gel chromatography (Hexane:EtOAc 2:1(v/v)) to give the title compounds (3B) (2.52 g, 90%). LC-MS (ESR): m/z=280 (M+H)+.

Provenance & Evidence