HCID 58192767, compound → HCID 58192802, compound

Participants

Reaction Conditions

Reaction Steps

At −78° C., to a solution of 7B (400 mg, 1.51 mmol) in 5 mL of THF was added MeLi (1.6 M in ether, 2.36 mL, 3.78 mmol) dropwise. The mixture was stirred at −78° C. for 30 minutes before it was quenched by 5 mL of NH4Cl aq (Sat'd) solution. The mixture was extracted by DCM (5 mL×3) and the combined DCM layers were dried over Na2SO4. Solvent was remove under vacuum and the residue was purified by silica gel chromatography [0 to 5% of MeOH in DCM:Hexane 1:1(v/v)] to give the title compounds (9A) as a mixture of equatorial and axial isomers (310 mg, 7.3%)). LC-MS (ESR): m/z=282 (M+H)+.

Provenance & Evidence