HCID 66580037, compound → HCID 62056677, compound

HRID 2092658Notes

Reaction equation

HRID 2092658 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[F:14][C:13]([F:15])([F:16])[CH2:12][CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 66580037HCID 66580037, compound

Product 1

HCID 62056677HCID 62056677, compoundYield 36.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

nitro-4-(3,3,3-trifluoro-propoxy)-benzene (1.4 g) in methanol (50 ml) was hydrogenated over Pd/C at RT and at atmospheric pressure for 12 h. The catalyst was filtered off and the solvent was removed in vacuo to give the desired 4-(3,3,3-trifluoro-propoxy)-phenylamine (0.45 g) as a light brown solid. MS (ESI, m/e): 206.1 (MH+).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-ebefb0841d99436e85e7c70b712f1a74
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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