Chloroform → 2-[[6-(3-Aminopiperidin-1-yl)-5-chloro-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile

HRID 209266Notes

Reaction equation

HRID 209266 reaction equation
[Cl:30][CH:31]([Cl:32])[Cl:33].[NH2:1][CH:2]1[CH2:3][N:4]([c:8]2[cH:9][c:10](=[O:25])[n:11]([CH3:24])[c:12](=[O:23])[n:13]2[CH2:14][c:15]2[c:16]([C:17]#[N:18])[cH:19][cH:20][cH:21][cH:22]2)[CH2:5][CH2:6][CH2:7]1.[S:26]([Cl:27])([Cl:28])=[O:29]>>[NH2:1][CH:2]1[CH2:3][N:4]([c:8]2[c:9]([Cl:28])[c:10](=[O:25])[n:11]([CH3:24])[c:12](=[O:23])[n:13]2[CH2:14][c:15]2[c:16]([C:17]#[N:18])[cH:19][cH:20][cH:21][cH:22]2)[CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 111635842-((6-(3-Amino-1-piperidinyl)-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl)benzonitrile

Product 1

HCID 113148062-[[6-(3-Aminopiperidin-1-yl)-5-chloro-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile

Sources & evidence

ORD record
ord-3a43cd1b1e9d4bddb911455040c7c2b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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