HCID 66579525, compound → HCID 52911464, compound

HRID 2092660Notes

Reaction equation

HRID 2092660 reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][C:13]3([CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]3)[C:12]2=[O:22])=[CH:7][CH:6]=1.[CH2:25]([Mg]Cl)[CH2:26][CH3:27]>>[OH:21][C:18]1([CH2:25][CH2:26][CH3:27])[CH2:17][CH2:16][C:13]2([C:12](=[O:22])[N:11]([C:8]3[CH:9]=[CH:10][C:5]([O:4][CH2:3][C:2]([F:1])([F:23])[F:24])=[CH:6][CH:7]=3)[CH2:15][CH2:14]2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 66579525HCID 66579525, compoundHCID 178455855HCID 178455855, compound

Product 1

HCID 52911464HCID 52911464, compound

Procedure

The title compound was prepared in analogy to example 55 from 2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-2-aza-spiro[4.5]decane-1,8-dione (obtained in example 86, step 1) by reaction with propylmagnesium chloride (2M in diethyl ether). MS (m/e): 368.2 [(M-H2O)H+].

Sources & evidence

ORD record
ord-1317be32576e46949d137055e3fa8271
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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