Hydrochloric Acid → HCID 66581289, compound

Participants

Reaction Steps

10-[4-(3-Methoxy-propyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (460 mg, obtained in example 130, step 3) was dissolved in tetrahydrofuran (12 mL). Then hydrochloric acid (2M, 6.40 mL) was added dropwise over a period of 10 minutes and the mixture was stirred for 3 hours at RT. The reaction mixture was poured into ice/water and was extracted two times with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, filtered and the solvent was evaporated. The residue was purified by flash chromatography (silica gel, gradient of heptane in ethyl acetate) to give the title compound as a colorless solid (128 mg, 32%). MS (m/e): 316.2 [MH+].

Provenance & Evidence