4-(Trifluoromethoxy)benzylamine → HCID 58230102, compound

HRID 2092694Notes

Reaction equation

HRID 2092694 reaction equation
C(O[C:4]([C:6]1([CH2:13][CH2:14]OC)[CH2:11][CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]1)=[O:5])C.[F:17][C:18]([F:29])([F:28])[O:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH2:25])=[CH:22][CH:21]=1>>[OH:12][CH:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:25]([CH2:24][C:23]3[CH:26]=[CH:27][C:20]([O:19][C:18]([F:17])([F:28])[F:29])=[CH:21][CH:22]=3)[CH2:14][CH2:13]2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 582299764-Hydroxy-1-(2-methoxy-ethyl)-cyclohexanecarboxylic acid ethyl ester

Product 1

HCID 58230102HCID 58230102, compound

Procedure

The title compound was prepared in analogy to example 108, step 3 from 4-hydroxy-1-(2-methoxy-ethyl)-cyclohexanecarboxylic acid ethyl ester (obtained in example 2, step 3) by treatment with 4-trifluoromethoxybenzylamine as a mixture of cis and trans diastereomers. Light yellow viscous oil. MS (m/e): 344.147 [MH+].

Sources & evidence

ORD record
ord-6058f0405fff42879dba8ddca9031610
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

Loading…