1-(4-Bromo-phenyl)-2,2-difluoro-propan-1-ol → 10-[4-(2,2-Difluoro-1-hydroxy-propyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Participants

Reaction Steps

The title compound was prepared in analogy to example 133, step 4 from 1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (0.8 g) (described in example 133 step 3) and 1-(4-bromo-phenyl)-2,2-difluoro-propan-1-ol (1.14 g) (synthesis: R. Mogi, et al, Journal of Fluorine Chemistry; 10; 2007; p 1098) and the crude product was directly used in the next step.

Provenance & Evidence