HCID 58230043, compound → HCID 58230107, compound

HRID 2092696Notes

Reaction equation

HRID 2092696 reaction equation
[F:1][C:2]([F:24])([CH3:23])[CH:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][C:13]3([CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]3)[C:12]2=[O:22])=[CH:7][CH:6]=1)[OH:4].[C:25]([Mg]Br)([CH3:27])=[CH2:26]>>[F:24][C:2]([F:1])([CH3:23])[CH:3]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:15][CH2:14][C:13]3([CH2:20][CH2:19][C:18]([OH:21])([C:25]([CH3:27])=[CH2:26])[CH2:17][CH2:16]3)[C:12]2=[O:22])=[CH:9][CH:10]=1)[OH:4]

Participants

3

Reactant 2

HCID 58230043HCID 58230043, compoundHCID 178456138HCID 178456138, compound

Product 1

HCID 58230107HCID 58230107, compound

Procedure

The title compound was prepared in analogy to example 55 from (2-(4-(2,2-difluoro-1-hydroxypropyl)phenyl)-2-aza-spiro[4.5]decane-1,8-dione by reaction with isopropenylmagnesium bromide (0.5 M in THF) as a white solid. MS (m/e): 379[M+].

Sources & evidence

ORD record
ord-2e423867879044e2b90895968e392a10
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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