HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 1-(4-Bromophenyl)-2,2-difluoroethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-(4-Bromophenyl)-2,2-difluoroethan-1-one | HCID 15271393 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Bromophenyl)-2,2-difluoroethan-1-ol | HCID 15942204 | — |
Reaction Steps
The title compound was prepared from 1-(4-bromo-phenyl)-2,2-difluoro-ethanone (1.6 g) (for synthesis, e.g.: G. K. Prakash et al; Journal of Fluorine Chemistry; 112; 2001; p 357) by standard reduction with NaBH4 (0.515 g) in THF (20 ml) at RT and 2 h reaction time as colorless oil (1.23 g). MS (m/e)=236 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440710B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-b1fdee61653b4c5c9e7db3a6271252eb |
| Source note | uspto-grants-2013_05 |