HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Bromophenyl)-2,2-difluoroethan-1-ol → 10-[4-(2,2-Difluoro-1-hydroxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Bromophenyl)-2,2-difluoroethan-1-ol | HCID 15942204 | — |
| Reactant | 1,4-Dioxa-10-azadispiro[4.2.4.2]tetradecan-9-one | HCID 58230108 | — |
| Product | 10-[4-(2,2-Difluoro-1-hydroxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one | HCID 58229955 | — |
Reaction Steps
The title compound was prepared in analogy to example 133, step 4 from 1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (described in example 133, step 3) and 1-(4-bromo-phenyl)-2,2-difluoro-ethanol as yellow solid. MS (m/e): 368.166 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440710B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-ad1cf630bbfc42ff99032adfddc46f5d |
| Source note | uspto-grants-2013_05 |