HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Isopropylaniline → 8-Hydroxy-2-(4-isopropylphenyl)-2-aza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Isopropylaniline | HCID 7464 | — |
| Reactant | 4-Hydroxy-1-(2-methoxy-ethyl)-cyclohexanecarboxylic acid ethyl ester | HCID 58229976 | — |
| Product | 8-Hydroxy-2-(4-isopropylphenyl)-2-aza-spiro[4.5]decan-1-one | HCID 52911982 | — |
Reaction Steps
The title compound was prepared in analogy to example 108, step 3 from 4-hydroxy-1-(2-methoxy-ethyl)-cyclohexanecarboxylic acid ethyl ester (obtained in example 2, step 3) by treatment with 4-isopropylaniline as a mixture of cis and trans diastereomers. Light brown solid. MS (m/e): 288.1 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440710B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-58f102e23233411e96198e339310c383 |
| Source note | uspto-grants-2013_05 |