HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cerium trichloride → 8-Hydroxy-8-(prop-1-en-2-yl)-2-(4-(trifluoromethyl)phenyl)-2-aza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cerium trichloride | HCID 161282 | — |
| Reactant | 2-(4-Trifluoromethyl-phenyl)-2-aza-spiro[4.5]decane-1,8-dione | HCID 58230172 | — |
| Reactant | HCID 178456138 | HCID 178456138 | — |
| Product | 8-Hydroxy-8-(prop-1-en-2-yl)-2-(4-(trifluoromethyl)phenyl)-2-aza-spiro[4.5]decan-1-one | HCID 58229949 | — |
Reaction Steps
The title compound was prepared in analogy to example 55 from 2-(4-trifluoromethyl-phenyl)-2-aza-spiro[4.5]decane-1,8-dione (product of example 208, step 2) by reaction with isopropenylmagnesium bromide (0.5 M in THF), but without use of anhydrous cerous(III)-chloride in the reaction, as a light yellow solid. MS (m/e): 353 [M F].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440710B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-452506a4765f486498878e5892c9db03 |
| Source note | uspto-grants-2013_05 |