反应详情

A mixture of tert-butyl (1S,2R)-2-(4-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate (94 mg, 0.22 mmol) and TFA (1 mL, 12.98 mmol) in DCM (1 mL) was stirred at RT for 2 h. The mixture was subsequently concentrated. The residue was purified by preparative HPLC (01-25; 5.45 min) and basified to give the title compound as a yellow solid (10 mg, 14%). 1H NMR (500 MHz, DMSO-d6) δ ppm 122-1.61 (m, 8H), 3.63 (s, 3H), 4.19 (s, 2H), 6.46 (br s, 1H), 7.98 (s, 1H), 8.29 (s, 1H), 8.85 (s, 1H). [M+H] calc'd for C17H22N6O, 327. found, 327.

1. concentrationThe mixture was subsequently concentrated
2. customThe residue was purified by preparative HPLC (01-25; 5.45 min)