Triethylamine → HCID 67237473, 화합물

HRID 2092797노트

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HRID 2092797 반응식
[CH3:1][N:2]1[C:6]([CH3:7])=[C:5]([C:8]2[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:12]([CH3:19])[N:11]=[C:10](S(C)(=O)=O)[N:9]=2)[CH:4]=[N:3]1.[NH2:24][C@@H:25]1[CH2:30][CH2:29][CH2:28][CH2:27][C@@H:26]1[NH:31][C:32](=[O:38])[O:33][C:34]([CH3:37])([CH3:36])[CH3:35].CCN(CC)CC>CC(N(C)C)=O>[C:34]([O:33][C:32]([NH:31][C@H:26]1[CH2:27][CH2:28][CH2:29][CH2:30][C@H:25]1[NH:24][C:10]1[N:9]=[C:8]([C:5]2[CH:4]=[N:3][N:2]([CH3:1])[C:6]=2[CH3:7])[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:12]([CH3:19])[N:11]=1)=[O:38])([CH3:37])([CH3:35])[CH3:36]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1514389(1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protectedHCID 58317607HCID 58317607, 화합물

생성물 1

HCID 67237473HCID 67237473, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A solution of ethyl 4-(1,5-dimethyl-1H-pyrazol-4-yl)-6-methyl-2-(methylsulfonyl)pyrimidine-5-carboxylate (0.07 g, 0.207 mmol), tert-butyl (1S,2R)-2-aminocyclohexylcarbamate (0.089 g, 0.414 mmol) and Et3N (0.115 mL, 0.827 mmol) in DMA (3 mL) was heated in a sealed tube at 90° C. for 8 h. The reaction mixture was poured slowly onto ice to yield a pale yellow precipitate, which was isolated by vacuum filtration, washed with water, and dried under vacuum to give the title compound. [M+H] calc'd for C24H36N6O4, 473; found, 473.

후처리

  1. additionThe reaction mixture was poured slowly onto ice
  2. customto yield a pale yellow precipitate
  3. customwhich was isolated by vacuum filtration
  4. washwashed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-286f60f5c55f49ec8c7b9d8371bb7f2b
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440689B2

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