HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Varenicline dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene | HCID 170361 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | Varenicline dihydrochloride | HCID 50878597 | — |
Reaction Steps
Varenicline base (2.3 g) was suspended in 20 mL of MTBE. Hydrochloric acid (1.1 g of 37% aqueous solution) was added and the mixture was stirred for 3 h at room temperature. The mixture was filtered and dried under vacuum at 40° C. XRD Analysis: Form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440825B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-22049f06c76f4a838c5338aaffcdb034 |
| Source note | uspto-grants-2013_05 |