Dimethylamine → HCID 42606695, compound

Participants

Reaction Steps

To a solution of 85 mg of the compound obtained in stage 8 of Example 1 in 500 μL of THF are added at room temperature 2 mL (29 equivalents) of a 2 M dimethylamine solution in THF. The reaction medium is then stirred for 2 hours before being dry evaporated. The obtained white solid is taken up in 10 mL of ethyl acetate. The resulting organic phase is washed several times with water and then with a saturated NaCl solution, dried on sodium sulphate, dry evaporated. The raw product is chromatographed on silica gel (dichloromethane/methanol:98/2) in order to provide 45 mg of the expected compound as a white solid.

Provenance & Evidence