1-Methylpiperazine → HCID 42606699, compound

Participants

Reaction Steps

To 92 mg of a solution of the compound obtained in stage 8 of Example 1 in 450 μL of dichloromethane, are added at room temperature 82 μL of N-methylpiperazine (5 equivalents). The reaction medium is stirred for 2 hours before being dry evaporated. The obtained white solid is taken up in 10 mL of ethyl acetate. The resulting organic phase is washed several times in water and then with a saturated NaCl solution, dried on sodium sulphate, dry evaporated. The raw product is chromatographed on silica gel (dichloromethane/methanol:98/2) in order to provide 53 mg of the expected compound as a white solid.

Provenance & Evidence