HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-cyclopropyl-2-(2-phenylethynyl)thiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 21105417 | HCID 21105417 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-cyclopropyl-2-(2-phenylethynyl)thiazole-4-carboxamide | HCID 51354792 | — |
Reaction Steps
Cyclopropylamine (2.49 mg, 0.00436 mmol), 1-hydroxybenzotriazole (0.589 mg, 0.00436 mmol), triethylamine (1.82 μL, 0.0131 mmol), N-(3-dimethylaminopropyl-N′-ethylcarbodiimide hydrochloride (2.09 mg, 0.0109 mmol) and CH2Cl2 (2 mL) were combined, and then 2-phenylethynyl-thiazole-4-carboxylic acid (10 mg, 0.004 mmol) was added. The reaction was left standing for about 16 hours and then purified by preparative HPLC. LC/MS (Method 5), RT=1.33 min. Calculated [M+H]+=269; Observed [M+H]+=269.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440837B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c53193bb42284910a980ac325dcfeaa3 |
| Source note | uspto-grants-2013_05 |