Cornforth reagent → HCID 51356495, compound

Participants

Reaction Steps

To a solution of phenyl-(2-phenylethynyl-thiazol-5-yl)-methanol (Example 234, 157 mg, 0.539 mmol) in dichloromethane (5.0 mL) was added pyridinium dichromate (243 mg, 0.647 mmol) and the reaction was stirred at room temperature for about 18 hours. The mixture was then diluted with EtOAc (15 mL), filtered over Celite® and washed with EtOAc. The solution was concentrated under reduced pressure and purified by preparative TLC, eluting with 20% EtOAc in hexanes, to afford the titled compound, phenyl-(2-phenylethynyl-thiazol-5-yl)-methanone (135 mg, 87%) as pale yellow oil.

Provenance & Evidence