HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylbarbituric acid → 3-Amino-N-cyclopropyl-2-hydroxyhexanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylbarbituric acid | HCID 69860 | — |
| Reactant | Allyl 1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamate | HCID 67246609 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Amino-N-cyclopropyl-2-hydroxyhexanamide | HCID 20804982 | — |
Reaction Steps
Allyl 1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamate bound resin M1B (30 g, 1.0 eq.) was swollen with DCM. 1,3-Dimethylbarbituric acid (24.17 g, 12 eq.) and tetrakis(triphenylphosphine)palladium (1.49 g, 0.1 eq.) were added and the mixture shaken overnight. The mixture was filtered and washed with DMF and DCM to yield the resin M1D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440706B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c89d013ba25e4197a1daef65dd2fe5d1 |
| Source note | uspto-grants-2013_05 |